Why myeloproliferative neoplasms progress

Myeloproliferative neoplasms (MPNs) often behave like slow-moving blood cancers, but they are biologically unstable. Over time, genetic damage, chronic inflammation, and changes in the bone marrow can allow the disease to become more aggressive.  READ MORE…

MPN Cancer and physical activity

Physical activity (PA) has been recognized as an effective non-pharmacological approach to alleviate symptoms and improve quality of life in cancer patients. However, little is known about how MPN patients engage in PA and the factors   READ MORE…

platelet counts in mpn cancer patients

Platelets, also known as thrombocytes, are tiny blood cells that play a vital role in blood clotting. They help to stop bleeding by clumping together and forming a plug at the site of a damaged blood vessel.  In patients with MPN (Myeloproliferative Neoplasms) cancer, platelet counts can be significantly affected, leading to various complications.   READ MORE…

MPN cancer awareness month & the importance of governor influence

In their respective states, governors possess significant authority and influence. They play a crucial role in commemorating and recognizing notable events and causes through proclamations. Through such actions, awareness is raised, unity is fostered, and individuals or communities are honored.  READ MORE…

incedence of mpns in sweden

This article discusses a comprehensive population-based study conducted in Sweden that aimed to assess the trends and distribution of MPN incidence across different subgroups and age populations.   READ MORE…

impact of host lifestyle and environmental factors

Beyond genetics, a complex interplay of host factors (aging, clonal hematopoiesis, immune dysregulation, and the gut microbiome), lifestyle choices (smoking, diet, obesity, and physical activity), environmental exposures (radiation and chemicals like benzene), and socioeconomic conditions significantly influences MPN risk, progression, and outcomes, highlighting the potential of prevention through lifestyle and environmental interventions. READ MORE…

enhancing treatment effectiveness in mpns

The scientific publication titled “Dual targeting of JAK2 and ERK interferes with the myeloproliferative neoplasm clone and enhances therapeutic efficacy” explores the potential of targeting both the JAK2 pathway and the MAPK pathway, specifically the ERK kinase, as a novel therapeutic strategy for MPNs.  READ MORE…

what makes mpns different from other blood cancers

Myeloproliferative neoplasms (MPNs) occupy a unique place among blood cancers. While they arise from malignant changes in blood-forming stem cells, they often behave very differently from acute leukemias, lymphomas, and related myeloid disorders. Understanding these differences is essential for accurate diagnosis, appropriate treatment, and realistic expectations for patients living with MPNs. READ MORE…

Inflammation, Histamine, and Itching in MPN: Why the Symptom Is More Than Skin-Deep

Itching—known medically as pruritus—is one of the most common and burdensome symptoms in myeloproliferative neoplasms (MPNs). For many patients, the itching is not mild or occasional, but burning, stinging, tingling, or electric, often triggered by water, heat, exercise, temperature changes, or even stress. In polycythemia vera (PV), the phenomenon is so characteristic that it has its own name: aquagenic pruritus.

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